Selected Publications
1.LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene.
Ambrosio S1, Amente S2, Saccà CD1, Capasso M2,3, Calogero RA4, Lania L2, Majello B1.
2.Cell cycle-dependent resolution of DNA double-strand breaks
Ambrosio, Susanna; Di Palo, Giacomo; Napolitano, Giuliana; Amente, Stefano; Dellino, Gaetano Ivan; Faretta, Mario; Pelicci, Pier Giuseppe; Lania, Luigi; Majello, Barbara
3.Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
Amente, Stefano; Milazzo, Giorgio; Sorrentino, Maria Cristina; Ambrosio, Susanna; Di Palo, Giacomo; Lania, Luigi; Perini, Giovanni; Majello, Barbara
4.Chemical characterization, antioxidant and cytotoxic activities of the methanolic extract of Hymenocrater longiflorus grown in Iraq
Al-Anee, Rafal S A; Sulaiman, Ghassan M; Al-Sammarrae, Khulood W; Napolitano, Giuliana; Bagnati, Renzo; Lania, Luigi; Passoni, Alice; Majello, Barbara
5.In vitro Studies of the cytotoxicity and cell cycle arrest of Hymenocrater longiflorus plant extract on colon cancer (RKO) cell line
Rafal S.A. Al-Anee*; Ghassan M. Sulaiman; Khulood W. Al-Sammarrae; Giuliana Napolitano; Renzo Bagnati; Luigi Lania; Alice Passoni; Barbara Majello
6.Amente, S., Milazzo,G., Sorrentino MC., Ambrosio, S., Di Palo, G., Lania,L., Perini,G. and Majello,B. Oncotarget (2015)
7.Ambrosio S, Amente S, Napolitano G, Di Palo G, Lania L, Majello B. MYC impairs resolution of site-specific DNA double-strand breaks repair. Mutat Res. (2015) 774:6-13. doi: 10.1016/j.mrfmmm.2015.02.005. Epub 2015 Mar 4.
8.Myc proteins in cell biology and pathology. Majello B, Perini G. Biochim BiophysActa.(2015)1849(5):467-8.doi:10.1016/j.bbagrm.2014.12.006. Epub 2014 Dec 20
9.Napolitano G, Lania L, Majello B. (2014) Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity. Biomed Res Int. 643805. doi: 10.1155/2014/643805. Epub 2014 Feb 19
10.Napolitano G, Amente S, Lavadera ML, Di Palo G, Ambrosio S, Lania L, Dellino GI, Pelicci PG, Majello B (2013). Sequence-specific double strand breaks trigger P-TEFb-dependent Rpb1-CTD hyperphosphorylation.. Mutation
Research, vol. 749, p. 21-27, ISSN: 0027-5107, doi: 10.1016/j.mrfmmm.2013.07.005
11.Napolitano G., Lania L., Majello B. (2013). RNA polymerase II CTD modifications: How many tales from a single tail. Journal of Cellular Physiology, p. Epub ahead of print, ISSN: 0021-9541, doi: 10.1002/jcp.24483
12.Amente S, Lania L, Majello B (2013). The histone LSD1 demethylase in stemness and cancer transcription programs.. Biochimica Et Biophysica Acta, vol. 1829, p. 981-986, ISSN: 0006-3002, doi:
10.1016/j.bbagrm.2013.05.002
13.Amente S, Zhang J, Lavadera ML, Lania L, Avvedimento EV, Majello B (2011). Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression.. Nucleic Acids Res,,
vol. 39, p. 9498-9507, ISSN: 0305-1048, doi: 10.1093/nar/gkr638
14.Amente, S., S., Bertoni A., Morano A., Lania L., Avvedimento V., Majello B. (2010). LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription.. Oncogene, vol. 29, p. 3691-3702, ISSN: 0950-9232, doi:
10.1038/onc.2010.120
15.Amente S., Lania L., Avvedimento V., Majello B. (2010). DNA oxidation drives Myc mediated transcription.. Cell Cycle, vol. 9, p. 3002-3004, ISSN: 1538-4101, doi: 10.4161/cc.9.15.12499
16.Amente,S., Gargano,B., Napolitano, G., Lania,L., and Majello,B. (2009) Camptothecin releases P-TEFb from the inactive 7SK snRNP complex. Cell Cycle, 7, 1249-1255.
17.Licciardo, P., Amente, S., Ruggiero, L., Monti, M., Pucci, P., Lania, L. and Majello, B. (2003) The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. Nucleic Acids Res, 31, 999-1005.
18.Napolitano, G., Mazzocco, A., Fraldi, A., Majello, B. and Lania, L. (2003) Functional inactivation of Cdk9 through oligomerization chain reaction. Oncogene, 22, 4882-4888.
19.Licciardo, P., Ruggiero, L., Lania, L. and Majello, B. (2001) Transcription activation by targeted recruitment of the RNA polymerase II CTD phosphatase FCP1. Nucleic Acids Res, 29, 3539-3545
20.Majello, B., Napolitano, G. Giordano, A and Lania, L. (1999) Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo Oncogene 18, 4598-605
21.Majello, B., Napolitano, G., De Luca, P. and Lania, L. (1998) Recruitment of human TBP selectively activates RNA polymerase II TATA-dependent promoters. J Biol Chem, 273, 16509-16516
22.Majello, B., De Luca, P. and Lania, L. (1997) Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem, 272, 4021-4026.
23.Majello, B., De Luca, P., Suske, G. and Lania, L. (1995) Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins. Oncogene, 10, 1841-1848
24.Majello, B., De Luca, P., Hagen, G., Suske, G. and Lania, L. (1994) Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1. Nucleic Acids Res, 22, 4914-4921
25.La Mantia, G., Majello, B., Di Cristofano, A., Strazzullo, M., Minchiotti, G. and Lania, L. (1992) Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: accurate transcription initiation is controlled by an Inr-like element. Nucleic Acids Res, 20, 4129-4136.
26.Majello, B., Arcone, R., Toniatti, C. and Ciliberto, G. (1990) Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. Embo J, 9, 457-465
27.Majello, B., Kenyon, L.C. and Dalla-Favera, R. (1986) Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Proc Natl Acad Sci U S A, 83, 9636-9640
28.Majello, B., La Mantia, G., Simeone, A., Boncinelli, E. and Lania L. (1985) Activation of major histocomptibility complex class I mRNA containing an Al-like repeat in polyomvirus-transformed rat cells. Nature 314, 45-9.